DISCIPLINE CENTRIC ELECTIVE COURSES
CODE: ZOO-HE-5016
COMPUTATIONAL BIOLOGY and BIOSTATICS
THEORY (Credits 4)
Unit 1: Introduction to Bioinformatics
Importance, Goal, and Scope of Bioinformatics
Applications and Limitations of Bioinformatics
Unit 2: Biological Databases: Introduction to biological databases
Primary, Secondary and Composite Databases
Nucleic Acid Databases (GenBank, DDBJ, EMBL and NDB);
Protein Databases (PIR, SWISS-PROT, TrEMBL, PDB);
Metabolic Pathway Databases (KEGG, EcoCyc, and MetaCyc);
Small Molecule Databases (PubChem, Drug Bank, ZINC, CSD)
Unit 3: Data Generation and DataRetrieval
Sequence Submission Tools (BankIt, Sequin, Webin)
Sequence File Formats in Bioinformatics (Flat file, GCG format, EMBL format, FASTA format)
Sequence Annotation in Bioinformatics
Data Retrieval Systems in Bioinformatics (SRS and ENTREZ)
Unit 3: Basic Concepts of Sequence Alignment
Scoring Matrices: PAM and BLOSUM
Methods of Alignment ( Dot Matrix Method, Dynamic Programming, BLAST, FASTA)
Local and global alignment,
Pair wise and multiple sequence alignments
Similarity, identity and homology of sequences.
Unit 4: Applications of Bioinformatics
Structural Bioinformatics (3-D protein, PDB),
Functional genomics (genome- wide and high throughput approaches to gene and protein function),
Drug discovery method (Basic concepts)
Unit 5: Biostatistics
Introduction,
Calculation of standard deviation,
Standard error,
Co[1]efficient of Variance,
Chi-square test,
Z test,
t-Test
